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KasA Inhibitor Synthesis for Potential Tuberculosis Treatment
By Jay Boudreau, Amna Naz The purpose of this research was to synthesize a lead compound for use as a possible tuberculosis drug. A Grignard addition was performed on 1-bromo-4-chlorobenzene to form 4-(4-chlorophenyl)-1-(phenylmethyl)-4-piperidinol. A separate alcohol, 1-naphthalenemethanol, was chlorinated to 1-(chloromethyl)-naphthalene. Not enough Grignard product was produced, so a deprotected Grignard product was alkylated through…
