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Synthesis of KasA Inhibitors
By Emma Ostrander, Caroline Pitches Faculty mentor: Dr. Davis Oldham In order to treat tuberculosis, specific KasA enzyme competitive inhibitors must be synthesized. This was done by doing a Grignard reaction, chlorination of an alcohol, and alkylation. For the Grignard reaction, bromobenzene was mixed with magnesium and then mixed with 1-benzylpiperidin-4-one. Ammonium chloride was then…
