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KasA Inhibitor Synthesis for Potential Tuberculosis Treatment
By Jay Boudreau, Amna Naz The purpose of this research was to synthesize a lead compound for use as a possible tuberculosis drug. A Grignard addition was performed on 1-bromo-4-chlorobenzene to form 4-(4-chlorophenyl)-1-(phenylmethyl)-4-piperidinol. A separate alcohol, 1-naphthalenemethanol, was chlorinated to 1-(chloromethyl)-naphthalene. Not enough Grignard product was produced, so a deprotected Grignard product was alkylated through […]
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Antibiotic Sensitivity Assay using Bacillus Strain Resistant Phages
By Arianna Chase, Jay Boudreau Faculty mentor: Dr. Swati Agrawal Bacillus anthracis, the bacteria responsible for the serious infectious disease anthrax, can easily become antibiotic resistant. As inhalation anthrax has only a 55% survival rate with aggressive treatment, new ways of treating the disease have been looked at, alongside the similar bacteria, but less deadly, […]
